Abstract: Background: The favorable influences of saffron supplementation on metabolic diseases
have previously been shown. We aimed to assess the effects of saffron supplementation on blood pressure in adults. Methods: A systematic search was performed in Scopus, Embase, and the Cochrane
library databases to find randomized controlled trials (RCTs) related to the effect of saffron supplementation on blood pressure in adults up to March 2021. The primary search yielded 182 publications,
of which eight RCTs were eligible. Results: Our results showed that saffron supplementation resulted
in a significant decrease in systolic blood pressure (weighted mean difference (WMD): −0.65 mmHg;
95% CI: −1.12 to −0.18, p = 0.006) and diastolic blood pressure (DBP) (WMD: −1.23 mmHg; 95% CI:
−1.64 to −0.81, p < 0.001). Moreover, saffron supplementation reduced DBP in a non-linear fashion,
based on duration (r = −2.45, p-nonlinearity = 0.008). Conclusions: Saffron supplementation may
significantly improve both systolic and diastolic blood pressure in adults. It should be noted that the
hypotensive effects of saffron supplementation were small and may not reach clinical importance.
Keywords: saffron; blood pressure; systematic review; meta-analysis
